Influence of comorbidities on CD4+/CD8+ proportion in HIV-positive patients in Blumenau, State of Santa Catarina: a retrospective study

Abstract Introduction: The objective was to identify comorbidities related to HIV-positive patients in Blumenau, State of Santa Catarina. Methods: A retrospective, descriptive observational design study which analyzed data from 424 patients assisted by the sexually transmitted disease/acquired immunodeficiency syndrome (STD/AIDS) Specialized Care Service (SCS). Results: Of 424 medical records analyzed, 388 patients presented CD4 + /CD8 + ratios lower than 1. The most prevalent comorbidities were smoking, depression, alcoholism, and herpes zoster infection, in males and females. Conclusions: The most relevant comorbidity in both genders was herpes zoster, an important marker of immunity in patients. The lowest mean was observed among patients with neurotoxoplasmosis. Keywords : HIV infection. Comorbidities. CD4 + /CD8 + ratio.The major mediators of cellular immunity, T cells are divided into two main subtypes, the cluster of differentiation 4 (CD4 + ) helper and CD8 + cytotoxic T lymphocytes