The pathological role of ferroptosis in ischemia/reperfusion-related injury.

Ischemia/reperfusion (IR) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many IR models. In this review, we aim to revise the pathological process of IR and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in IR, providing evidence to support the targeting of ferroptosis in the IR pathway may present as a therapeutic intervention to alleviate IRI associated cell damage and death.