POTENTIAL EVALUATION OF ANTI - DIARRHEAL ACTIVITY OF LEAVES OF AGANOSMA DICHOTOMA IN MICE

The plant Aganosma dichotoma is widely used as traditio nal medicine in different aborigines which is supported by this investigation . It belongs to Apocynacae family. The aim of the study was to evaluate the methanolic extract of leaf of Aganosma dichotoma ’s different fractionates as anti - diarrheal agents. The methanolic extract of leaves of Aganosma dichotoma (400 mg/kg) exhibited very statistically significant anti - diarrheal activity with a 68.27 % reduction of diarrhea compared to the standard of loperamide 69.23 %. The anti - diarrheal activity shows Aganosma dichotoma statistica l l y significant at the higher dose compared to dose of 200 mg/kg . Therefore we can assume that , the anti - diarrheal activity of Aganosma dichotoma was dose dependent.