Self-Nanoemulsifying Drug Delivery System (SNEDDS) with Enhanched Solubilization of Ethanol Extract from Mangosteen Peels (Garcinia Mangostana, L.) for Treatment of Topical Gangrene Foot: Design and Optimization
2017
The aim of the present study is to develop and optimize self-nanoemulsifying drug delivery systems (SNEDDS) to improve
the topical bioavailability of poorly soluble ethanol extract of mangosteen peels and to get optimum method of SNEDDS
by simplex lattice design, using Design Expert software ®version 7. Solubility of ethanol extract of the mangosteen peels
was estimated in various compositions to select proper components combinations. Virgin coconut oil/ VCO (oil), Tween®
80 (surfactants) as well as polietilenglikol 400 (PEG 400) (co-surfactants) were employed to construct pseudo-ternary
phase diagrams. Transmittance and pH, droplet size, zeta potential, and thermodynamic stability were performed to
optimize formulations from phase diagram. Fourteen formulations composed of VCO, Tween 80 and PEG 400 at simplex
lattice design ratios were selected. The results showed that the ethanol extract of the mangosteen peels SNEDDS optimum
consisting of Cremophor EL as the surfactant, PEG 400 as the co-surfactant, and VCO as the oil phase with a ratio of 5.27:
1: 1.72. Evaluation of SNEDDS with an optimum formulation with drug loading value of 125 mg/5 mL, emulsification
time of 5,2 seconds, transmittance value of 74,6552 %, pH value 5,85 and has a particle size of 18,9 nm. Ethanol extract
of the mangosteen peels loaded SNEDDS, with enhanced solubilization and nanosizing, and has potential to improve the
absorption of drug and increase its topical antimicrobial activity against Staphylococcus aureus.
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