Insecticidal Amides with Selective Potency against a Resistant (Super-kdr) Strain of Houseflies (Musca domestica L.)

Insecticidal synthetic amides related to a novel lead compound, (2E, 4E)-N-isobutyl-6-phenyl-hexa-2, 4-dienamide, and to some natural isobutylamides are up to four times as effective for both knockdown and kill against houseflies with the super-kdr mechanism of resistance (which operates against DDT and pyrethroids) than against the S-strain. This selectivity in the response to N-alkylamides demonstrates that the non-metabolic resistance mechanism, super-kdr, is vulnerable to and might be combated effectively with N-alkylamides.