SOREM and CAP Parameters in Narcolepsy Patients and Healthy Subjects

This study aimed to compare sleep architects and CAP parameters between patients with Narcolepsy and the normal person using the electroencephalogram signal (EEG) analysis. In this study, we analyzed sleep data from five Narcolepsy patients and fourteen normal controls. Participants’ macrostructure parameters and CAP parameters were calculated and compared to indicate the abnormal in narcoleptics’ nocturnal sleep. A prime abnormal in Narcolepsy patient’s sleep structures was the early onset of REM with significant shot REM latency; this phenomenon was observed in two out of five patients’ hypnograms. The nocturnal sleep of Narcolepsy patients was usually disturbed by sleep arousals that appeared regularly at night, which reduced the quality of nocturnal slumber. In this study, Narcolepsy individuals had a lower CAP/NREM rate, shorter CAP total time, and a decreased in the A1 index during NREM sleep compared to healthy individuals. The obtained results suggested that people with Narcolepsy be likely to have a short REM latency with fragmented night sleep that reduced sleep quality. The increase in the CAP ratio could relate to the instability of night sleep in Narcolepsy patients. A further study on EEG wave activity should be conducted to assist the inequality between a group of Narcolepsy patients and another group of normal subjects.