Rapid and sensitive electrochemical detection of myricetin based on polyoxometalates/SnO2/gold nanoparticles ternary nanocomposite film electrode

Abstract Electrochemical detection of myricetin is rapid and economic but has been rarely reported so far. Here we present a layer-by-layer self-assembly strategy to fabricate a ternary nanocomposite film containing polyoxometalate P 2 W 18 clusters, mesoporous SnO 2 nanospheres and Au nanoparticles (AuNPs) on the ITO electrode for the electrochemical determination of myricetin. Compared with all the other electrodes herein and previously reported, the (P 2 W 18 -SnO 2 -AuNPs) 3 /ITO widened the electrochemical determination range of myricetin from 1 to 110 μmol/L with quick response time, which was extended for the myricetin detection in juice samples with satisfactory recoveries between 97.65% and 103.07%. The extraordinary electrocatalytic activity could be attributed to the synergetic contribution of three components, namely P 2 W 18 with multi-electron reversible electrocatalytic properties, mesoporous SnO 2 nanospheres with high conductivity and electroactive surface area, and AuNPs with outstanding conductivity and electrocatalytic properties. With superior stability, reproducibility and anti-interferences against common coexisting ions, the presented method would cater for the requirements of clinics and pharmaceuticals for the rapid and sensitive determination of myricetin in real samples.