The C terminus of p53 binds the N-terminal domain of MDM2

Mdm2 negatively regulates tumor suppressor p53 via binding to the transactivation and the DNA-binding domains of p53. Now work reveals a novel interaction between the N-terminal domain of Mdm2 and the extreme C-terminal region of p53, a region that bears the sites of many post-translational modifications that inhibit the Mdm2-p53 interaction.