A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice

Chen-Chun Pai,Rachel S. Deegan,Lakxmi Subramanian,Csenge Gal,Sovan Sarkar,Elizabeth Blaikley,Carol Walker,Lydia Hulme,Eric J. Bernhard,Sandra Codlin,Jürg Bähler,Robin C. Allshire,Simon K. Whitehall,Timothy C. Humphrey

A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice

2014

Chen-Chun Pai
Rachel S. Deegan
Lakxmi Subramanian
Csenge Gal
Sovan Sarkar
Elizabeth Blaikley
Carol Walker
Lydia Hulme
Eric J. Bernhard
Sandra Codlin
Jürg Bähler
Robin C. Allshire
Simon K. Whitehall
Timothy C. Humphrey

DNA double strand breaks are repaired by nonhomologous end-joining (NHEJ) or homologous recombination (HR) pathways. Here, Pai et al. discover that post-translational modification of lysine 36 of histone H3 plays a key role in determining double strand repair pathway choice.

Keywords:

Histone H3
Chromatin remodeling
Molecular biology
Histone
Genetics
Non-homologous end joining
DNA repair
DNA End-Joining Repair
Chromatin
Biology
Double Strand Break Repair

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