bicclicos compounds and their use as dual inhibitors of c-SRC / JAK

2011 
A compound of formula (I) having the structure: ** Formula ** wherein R1 is H, aryl, substituted aryl, alkyl, substituted alkyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl or substituted heterocyclylalkyl, X is CH2 or C> = O R2 is H, alkyl (C1-C6), halogen, CF3 or O-alkyl (C1-C6) Y is -NHCO-, -CONH-, -NHSO 2, -NH-, -NCH3-CO -, -NHCH 2, O, -NHCONH- or -NHCOCH2- R3 is alkyl, substituted alkyl, aryl or substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl or heterocycloalkyl where the term "alkyl" refers to aliphatic groups saturated alkyl groups including straight-chain alkyl branched chain groups, cycloalkyl (alicyclic) groups, alkyl substituted cycloalkyl groups and substituted alkyl groups with cycloalkyl; the term "cycloalkyl" refers to a saturated or partially saturated, monocyclic or fused or spiro polycyclic carbocycle; the term "heterocycloalkyl" or "heterocyclyl" refers to a ring system 3 to 10 membered non-aromatic, partially unsaturated or fully saturated, which includes single rings of 3 to 8 atoms and bi- ring systems or tri-cyclic can include aryl rings or aromatic six-membered heteroaryl fused to a non aromatic ring; the term "substituted" refers to substitution with one or more or any combination of the following substituents: hydroxy, halogen, carboxyl, cyano, nitro, oxo (> = O), thio (> = S), substituted or unsubstituted , substituted haloalkyl or unsubstituted alkoxy, substituted or unsubstituted, haloalkoxy substituted or unsubstituted, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, arylalkyl substituted or unsubstituted cycloalkyl, substituted or unsubstituted, substituted cycloalkenylalkyl or substituted cycloalkenyl substituted or unsubstituted, amino substituted or unsubstituted aryl, substituted or unsubstituted, substituted or unsubstituted heteroaryl, ring substituted heterocyclyl or unsubstituted ring substituted or unsubstituted heteroarylalkyl, substituted heterocyclic ring or unsubstituted, substituted or unsubstituted guanidine; or a pharmaceutically acceptable salt thereof.
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