Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures

INTRODUCTION The increased bone resorption that occurs in postmenopausal women is due to a lack of estrogen (E2), and can be prevented by estrogen replacement therapy [1]. The mechanism by which estrogen acts on bone is not fully understood, but it involves inhibition of the proliferation and differentiation of osteoclast precursors [2]. It has been proposed that the effects of estrogen on osteoclast differentiation are mediated by interactions [...]