P.1.010 The identification of protein tyrosine phosphatase, non-receptor type 1 in hippocampal modulation of food anticipatory behaviour

significant effect on mGlu2 receptor expression level [One-way ANOVA, F(3.41) = 22.8, p< 0.0001]. Moreover Dunnett’s Multiple Comparison Test analysis shows that level of mGlu2 receptor surface expression in cells after double thymidine block was significantly higher compared to receptor expression level in asynchronously growing cells (p< 0.01). In contrast, the expression level of mGlu2 receptor was significantly decreased in M phase blocked cells (p< 0.01) and cells after serum starvation (p< 0.01). Conclusions: The results indicate that modification of the inducible expression system by cell synchronisation seems to have significant effect on surface mGluR2 expression level.