Regional Cerebral Metabolism in Experimental Brain Infarction

Hemodynamic alterations in focal cerebral ischemia are now well documented by numerous studies. Reduction of rCBF in the early stages of experimental infarction (2, 11, 13), perifocal hyperemia and vasoparalysis, related steal phenomena, and the luxury perfusion syndrome are now familiar findings—both in experimental conditions and in human cerebrovascular accidents (GVA) (5, 10). Underlying and concomitant metabolic disturbances have been studied only recently (2, 4, 7, 8, 11). Little is known, however, about regional metabolic changes in focal cerebral ischemia.