Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient.
2008
Aurora B is a kinase important for mitosis, and is shown to generate a spatial gradient of phosphorylated substrates in anaphase with the highest concentration at the spindle midzone. Generation of this gradient involves a microtubule-dependent mechanism of aurora B activation. The gradient is proposed to provide important spatial information during mitosis.
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