Recent advances in polymeric nanomedicines for glioblastoma therapy

Glioblastoma (GBM) is the most common primary malignant tumor with high mortality. Currently, the treatment for GBM displays poor prognosis which is difficult to achieve a satisfied therapeutic effect. Nanomedicines based on polymers have opened up new strategies for GBM therapy due to their unique features such as good biocompability, easy designation and synthesis, feasible ligand functionalization, efficient blood brain barrier (BBB) penetration. Polymeric nanocarriers boost efficient antitumor efficacy via encapsulate/conjugate therapeutics including small molecule anticancer drugs, nucleic acids (DNA, siRNA) and proteins. Here, we review the research progress of chemotherapy, gene therapy, immunotherapy, synergistic therapy as well as various stimuli responsive polymeric nanosystems for GBM over recent years, and also prospect for their future development.