Synthesis of Diaminobutane Derivatives as Potent Ca2+-Permeable AMPA Receptor Antagonists.

Yoshiyuki Yoneda,Shinichi Kawajiri,Masunobu Sugimura,Ken Osanai,Fusako Kito,Emi Ota,Tetuya Mimura

Synthesis of Diaminobutane Derivatives as Potent Ca2+-Permeable AMPA Receptor Antagonists.

2002

Yoshiyuki Yoneda
Shinichi Kawajiri
Masunobu Sugimura
Ken Osanai
Fusako Kito
Emi Ota
Tetuya Mimura

Abstract We synthesized diaminobutane derivatives as potent Ca 2+ -permeable AMPA receptor antagonists with non-hypotensive activity. Compound 10c showed selective Ca 2+ -permeable AMPA receptor antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.

Keywords:

AMPA Receptor Antagonists
Combinatorial chemistry
AMPA receptor
Organic chemistry
Chemistry

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