Synthesis of Novel Tris-1,2,4-triazole Derivatives and Their Antibacterial Activity

A series of novel 3,3′,3″-[1,3,5-triazine-2,4,6-triyltris(azanediyl)]tris(5-aryl-1H-1,2,4-triazole-1-carbothioamide) derivatives were designed and synthesized through reaction of new tris-thiourea derivatives with thiosemicarbazide and sodium hydroxide in absolute ethanol under reflux conditions. The initial tris-thioureas were prepared by one-pot reaction of substituted benzoyl chlorides with potassium thiocyanate, followed by treatment with 1,3,5-triazine-2,4,6-triamine. The structures of the new tris-triazoles were identified on the basis of their spectral data. All newly synthesized tris-triazoles were screened for antibacterial activity against two gram-negative (Pseudomonas aeruginosa, Escherichia coli) and two gram-positive strains (Staphylococcus aureus, Bacillus cereus). All tested compounds exhibited promising antibacterial activities.