Clinical evaluation of Zataria Multiflora essential oil mouthwash in the management of recurrent Aphthous Stomatitis

The purpose of this study was to evaluate the efficacy of the topical use of 0.2% oral mouth wash of essential oil of zataria multiflora in the control of recurrent aphthous stomatitis (RAS). In this double-blind, randomized study each of 60 patients with RAS was assigned to one of the 2 management modalities. Those in group Areceived an oral rinse solution of Zataria multiflora essential oil, 3 times a day for 4 weeks and those in group B received placebo 3 times a day for 4 weeks. The patients were monitored two times weekly. A statistical Chi-Square test was performed to analyze the data. Zataria multiflora oral rinses was shown to be more efficacious than placebo in the treatment of patients with RAS.