Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer

Background The leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) is an adult intestinal stem cell marker frequently detected in human colorectal cancers (CRCs). However, the value of Lgr5 level in CRC prognosis and treatment prediction has not been well characterized.