Supressão da resposta imunitária humoral causada por citrinina efeito imunotóxico da citrinina Humoral immunoresponse discontinuance caused by citrinin

The present paper was done in order to determinate the immunotoxic effect caused by low dose exposure to citrinin (2,5mg.Kg· 1). Doing so, groups of tive albino mice were submitted to citrinin before, concomitantly and after immunization with inert antigen (sheep red blood cells- SRBC). The animais were bleed seven days following the mycotoxin exposure and, the antibodies and complement titration determined. and compared to a not-intoxicated control group. lt was detected a decrease of antibodies titration in ali the intoxicated animais. The citrinin exposure done before, as well as after SRBC sensitization caused a lowering of 87.5% on the primary antibodies levei. The simultaneous exposure, added to SRBC sensitization, caused a dropping equivalent to 75%. A remarkable complement lowering was also demonstrated on the previously intoxicated (93.75%), as well as, on the animais concomitantly sensitized and intoxicated with citrinin (87.5%). The effects of citrinin on T lymphocytes subsets, inflammatory processes and cellular presentation of was also discussed.