Synthesis, characterization, and crystal structure of sulfonamide chalcone: (E)-4-methoxy-N-(4-(3-(3,4,5-trimethoxyphenyl)acryloyl)phenyl)-benzenesulfonamide

The title sulfonamide chalcone derivative was synthesized by condensation reaction of N-(4-acetylphenyl)-4-methoxybenzenesulfonamide and 3,4,5-trimethoxybenzaldehyde in basic solution. The structure was determined using FT-IR, 1H-NMR and UV-Vis spectroscopy. The crystal structure was characterized by single crystal X-ray structure analysis: triclinic system, sp. gr. P \(\overline 1\), Z = 2; a = 7.9273(5), b = 9.3159(6), c = 18.0174(12) A, α = 94.6420(18)°, β = 93.0310(17)°, γ = 114.9200(15)°. In crystal packing, the molecules are linked by N–H···O hydrogen bonds into chains along the [100] direction. The crystal is further stabilized by weak C–H···O and C–H···π interactions.