Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations

Abstract This paper describes the development of an electrophoretic method used to analyse diuretics, and its use in the analysis of pharmaceutical formulations. Chlorthalidone, furosemide, hydrochlorothiazide and triamterene were separated in 5 min by micellar electrokinetic capillary chromatography using a carrier containing sodium dodecylsulphate as surfactant, and were subsequently detected spectrophotometrically using a diode-array detector. The limits of detection ( S/N =3) were in all cases less than 1.2 μg ml −1 for all compounds. Satisfactory repeatability was obtained for migration times (