Thienopyridine urea inhibitors of KDR kinase

Abstract A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2 , are potent inhibitors of KDR ( 2 indicated that this analog possessed excellent in vivo potency (ED 50 2.1 mg/kg) as measured in an estradiol-induced mouse uterine edema model.