Power Spectral Analysis of Heart Rate Variability in Rats as a Quantitative Tool in the PK-PD Analysis of the Parasympatholytic Activity of Atropine

Itay Perlstein,David Stepensky,Dan Sapoznikov,Amnon Hoffman

Power Spectral Analysis of Heart Rate Variability in Rats as a Quantitative Tool in the PK-PD Analysis of the Parasympatholytic Activity of Atropine

2001

Itay Perlstein
David Stepensky
Dan Sapoznikov
Amnon Hoffman

Purpose. To utilize power spectral analysis (PSA) of heart rate variability (HRV) as a pharmacodynamic (PD) measure of atropine parasympathetic effect, and to model the kinetics of action.

Keywords:

Atropine
Heart rate variability
Antagonist
Pharmacodynamics
Heart rate
PK/PD models
Parasympatholytic
Endocrinology
Chromatography
Chemistry
Pharmacokinetics
Internal medicine
Cardiology

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