T1912 Association Between Ccttt Pentanucleotide Repeat in the Inducible Nitric Oxide Synthase Promoter Polymorphism and Achalasia

averaging successive swallows cancels out extrinsic pressure from HREPT studies, isolating the intrinsic esophageal contraction. Topographic plots of peristalsis can thus be reduced in a coordinate-specific scheme to three sequential zones: inhibition-contraction-quiescence. Consequently, motility disorders can similarly be physiologically defined as impaired inhibition (achalasia), abnormal contraction (hyper or hypotensive peristalsis) or persistent contraction (spastic nutcracker) depending on the length-time coordinates of abnormal contractile activity.