New developments in protein structure-function analysis by MS and use of hydrogen-deuterium exchange

11 Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden2 Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden3 NVS Department, KI-Alzheimer’s Disease Research Center, Karolinska Institutet, Stockholm, SwedenKeywordsdeuterium exchange; ESI-MS; gas-phaseinteraction; ion mobility; protein structureCorrespondenceH. Jo¨rnvall, Division of PhysiologicalChemistry I, Department of MedicalBiochemistry and Biophysics, KarolinskaInstitutet, S-17177 Stockholm, SwedenFax: +46 8 33 74 62Tel: +46 8 524 87702E-mail: Hans.Jornvall@ki.se(Received 11 April 2011, revised 1 June2011, accepted 8 June 2011)doi:10.1111/j.1742-4658.2011.08215.x