Features of inflammation in the asthma patients with osmotic airway hyperresponsiveness

Introduction: Cytokines are the main tissue regulators of chronic inflammatory process at asthma and they play a key role in the development of airway hyperresponsiveness. Which of them cause the development of osmotic airway hyperresponsiveness has not been studied enough. Aim: To study the relationship between the bronchial patency, airway responsiveness to ultrasonically nebulized distilled water (UNDW) and cytokines profile in the expired breath condensate (EBC) and the blood serum. Methods: Lung function (FEV 1 ), airway response (ΔFEV 1 ) to 3-minute UNDW inhalation, the base level of cytokines (IL-4, IL-5, IL-6, IL-8, IFN-γ) in the EBC and blood serum were studied in 61 patients with uncontrolled asthma. Results: The patients were divided into 2 groups by the response to the provocation: with the positive airway response to UNDW and without it (mean ΔFEV 1 is -19.2±0.97 and -1.37±0.37%, respectively; p 1 =87.7±2.19 and 97.2±0.99%; p 1 (r=-0,48, p 1 drop in the response to UNDW depended on IL4 concentration (r=-0.42; p Conclusion: In asthmatics airway response to UNDW is closely connected with the IL4 and IFNγ in EBC and blood serum. Supported by Russian Science Foundation (grant 14-25-00019).