Epidemiology of prostate cancer from three centers and analysis of the first-fine hormonal therapy for the advanced disease

Objective To analyze the epidemiology information of prostate cancer from three centers of Bejing,Shanghai,Guangzhou,and to reflect the current situation of prostate cancer in China,and to analyze the information of 272 patients with advanced prostate cancer who received hormonal therapy to find the prognostic factors of hormone therapy.Methods Collect the information of 525 patients with prostate cancer from three centers.Two hundred and seventy-two cases of advanced prostate cancer with full information were selected from the 525 cases to analyze the prognostic factors of hormone therapy.Results Three hundred and fifty-seven cases(68.0%)had advanced disease at diagnosis and 80.2% patients received hormone therapy as the main therapy.Prognostic analysis indicared that Gleason score, bone metastasis and prostate specific antigen nadir were independent prognostic factors of progression-free survival time.Conclusions In this report,most patients are advanced prostate cancer at diagnose,and hormonal therapy is the main therapy.Gleason score,bone metastasis,prostate specific antigen nadir are independent prognostic factors of advanced prostate cancer after hormone therapy. Key words: Prostate cancer; Epidemiology; Hormonal therapy; Prognosis