The effect of 2 days vs 5 days regime of intravenous immunoglobulins on the outcome of patients suffering from severe guillain barre syndrome

Objective: To compare the mean time lapse till improvement of functional grades in 2 days regime of IVIG versus 5 days in severe pediatric guillain barre syndrome.Methodology: This randomized clinical trial was conducted in Children Hospital Lahore pediatric neurology department from August 2015 to February 2016 after ethical clearance. There were 64 patients with severe GBS were randomized into Group A which received IVIG 400mg/kg/day over 5 days and Group B which received 1 g/kg/day over 2 days, making 2 g/kg in both groups. The disability grade was done at the start of treatment on daily basis till decrease in GBS disability grade by grade 1. The data was entered on SPSS 25.Results: Both study groups were comparable for gender and age of the subject In this study out of 64 cases (32 in each group), 65.63%(n=21) in Group-A and 71.88%(n=23) Group-B were between 2-10 years of age while 34.37% (n=11) in Group-A and  28.12% (n=9) in Group-B were between 11-15 years, mean+sd was calculated as 8.69+3.48 and 8.34+3.27 years. The mean time lapse till improvement was significantly less in group B, 18.38±1.79 compared with group A, 22.09±2.16, p value 0.0001 which shows statistically significant improvement in group B regardless of gender and age of subjects.Conclusion: The mean duration for improvement of functional grades was significantly lower in GBS patients administered 2 days regime of IVIG as compared to5 days.