A kind of preparation method of cis Rosuvastatin calcium impurities

The invention discloses a kind of preparation method of cis Rosuvastatin calcium impurities; it is with (4R cis) 6 carboxaldehyde radicals 2; 2 dimethyl 1; the tert-butyl acetate of 3 dioxane 4 and [4 (4 fluorophenyl) 6 isopropyl 2 (N methyl N methylsulfonyls amido) 5 pyrimidine radicals] triphenylphosphinebromide are raw material; reacted through Witting, isomer separation, deprotection and hydrolysis, salt-forming reaction, be made target compound.The features such as this method has originality, simple to operate, convenient post-treatment, product purity height and high income.The beneficial effects of the invention are as follows：For rosuvastain calcium registration declare, produce in control and improve rosuvastain calcium quality certain help is provided.