Quantitative microfluidic fluorescence microscopy to study vaso-occlusion in sickle cell disease.

Vaso-occlusive crisis is the primary reason for emergency medical care sought by Sickle Cell Disease (SCD) patients.[1][1] In vivo imaging in transgenic SCD mice has identified molecular events that may promote vaso-occlusion.[2][2]–[4][3] However, the relevance of these mechanisms is not