The role of regioselective hydroxylation on toxicity of diclofenac and related derivatives

Ana C. S. P. S. de Jesus,Fernanda M. Costa,Paulo Alexandre Panarra Ferreira Gomes das Neves,Fernanda P. A. Melo,Antônio dos Santos Silva,Osmarina P.P. Silva,Cleydson Breno Rodrigues dos Santos,Rosivaldo S. Borges

The role of regioselective hydroxylation on toxicity of diclofenac and related derivatives

2019

Ana C. S. P. S. de Jesus
Fernanda M. Costa
Paulo Alexandre Panarra Ferreira Gomes das Neves
Fernanda P. A. Melo
Antônio dos Santos Silva
Osmarina P.P. Silva
Cleydson Breno Rodrigues dos Santos
Rosivaldo S. Borges

Diclofenac and related derivatives become more toxic after biotransformation reactions in the body by electron or hydrogen transfers. The structure–reactivity study on regioselective hydrox...

Keywords:

Regioselectivity
Toxicity
Hydroxylation
Chemistry
Computational chemistry
Diclofenac
Organic chemistry
Electron transfer
Hydrox
Biotransformation
Hydrogen

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