Comparative study of the muscarinic cholinoreceptors of the glial cells in the human and rat cerebral cortex

: Radioligand analysis was used to study and compare muscarinic cholino receptors from human and rat brain glial cells containing no neurospecific proteins. It was demonstrated that 3H-quinuclidinyl benzylate has a higher affinity for muscarinic cholino receptors of human glia (Kd 2.0 nM) than receptors of rat glial cells (Kd 9.1 nM). By pharmacological properties muscarinic cholinoreceptors of the glia differ from receptors of insect brain and are similar to cholinoreceptors from animal brain synaptosomes.