DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Claudio Sustmann,Steffen Dickopf,Jörg T. Regula,Hubert Kettenberger,Michael Molhoj,Christian Gassner,Diana Weininger,Sebastian Fenn,Tobias Manigold,Lothar Kling,Klaus-Peter Künkele,Manfred Schwaiger,Birgit Bossenmaier,Julia J. Griese,Karl-Peter Hopfner,Alexandra Graff-Meyer,Henning Stahlberg,Philippe Ringler,Matthias E. Lauer,Ulrich Brinkmann,Wolfgang Schaefer,Christian Klein

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

2019

ABSTRACTHigh specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we present a generic approach to...

Keywords:

Molecular biology
Biology
Antibody
Antibody-dependent cell-mediated cytotoxicity
Recombinant DNA
cancer therapy
Cancer research
Immune system
Drug development

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