Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Vincenzo Sorrentino,Mario Romani,Laurent Mouchiroud,John S. Beck,Hongbo Zhang,Davide D’Amico,Norman Moullan,Francesca Potenza,Adrien W. Schmid,Solène Rietsch,Scott E. Counts,Johan Auwerx

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

2017

Vincenzo Sorrentino
Mario Romani
Laurent Mouchiroud
John S. Beck
Hongbo Zhang
Davide D’Amico
Norman Moullan
Francesca Potenza
Adrien W. Schmid
Solène Rietsch
Scott E. Counts
Johan Auwerx

Amyloid-β peptide proteopathies disrupt mitochondria, and restoring mitochondrial proteostasis reduces protein aggregation in animal models of amyloid-β disease.

Keywords:

Cell biology
Proteotoxicity
Proteostasis
Protein aggregation
Biology
Amyloid
Peptide
Mitochondrion
Unfolded protein response
Mitochondrial unfolded protein response
Mitophagy
Mitochondrial Degradation
Mitochondrial translation

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