A total synthesis of (+)-eremantholide A

Abstract Stereoselective and enantiospecific total synthesis of (+)-eremantholide A ( 1 ) is described. The present total synthesis features 1) regio- and stereoselective radical carbocyclization of D-glucose-derived γ-lactone 7 , and 2) a nine-membered ring formation by the coupling reaction of bicyclic triflate 18 and known furanone 19 followed by a vinylogous aldol reaction.