Synthesis of 1-(2-methyl-2,3-dihydrobenzo (b)furan-5-yl)-3-phenyl-2-propen-1-one derivatives and analogues
2005
A series of new 1-(2-methyl-2,3-dihydrobenzo[b]furan-5-yl)-3-phenyl-2-propen-1-one derivatives (2b-k) were synthesized by the condensation of 1-(2methyl-2,3-dihydrobenzo[b]furan-5-yl)-1-ethanone with aromatic aldehydes. Analogously 1-(5-methoxy-2-methyl-2,3-dihydrobenzo[b]furan-6-yl)-3-phenyl2-propen-1-one (6) was obtained from 1-(5-methoxy-2-methyl-2,3-dihydrobenzo[b]furan-5-yl)-1-ethanone (5). The synthesized compounds were tested for anti-inflammatory activity. benzo[b]furan-5-yl)-3-phenyl-2-propen-1-ones, 1-(5-methoxy-2-methyl-2,3dihydrobenzo[b]furan-6-yl)-3-phenyl-2-propen-1-one, Claisen rearrangement, anti-inflammatory activity
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