Первые результаты клинического применения прямой генной терапии VEGF и bFgF при лечении пациентов с хронической ишемией нижних конечностей

The article shows the results of using the double cassette expression plasmid vector pBud-VEGF165-FGF2 for patients with peripheral arterial diseases (PAD): 10 men with PAD experienced intramuscular injection of studied medication to the affected limb. Foe explaining the findings was used the measurement of ankle-brachial index (ABI), treadmill test, recovery period of initial ABI after pressure, immunohistochemical study. Was recorded an improvement in functional status of limbs after using treatment by 19% according to ABI, an increase in walking distance twice, reduced time to restore the original LPI by 38%. According to immune histochemical study was recorded an increase in density of capillary network up to 47.9%.