Effect of Transcatheter Aortic Valve Implantation on the Immune Response Associated With Surgical Aortic Valve Replacement

Abstract The immune response following transcatheter aortic valve implantation (TAVI) in comparison to that following surgical aortic valve replacement (SAVR) remains to be fully elucidated. In a 2-part study, we assessed laboratory data obtained before, immediately after, and 24 and 48 hours after SAVR (128 patients; age ≥80 [mean 82] years) or transfemoral TAVI (102 patients; age ≥80 [mean 86] years) performed for aortic stenosis. In-hospital mortalities were similar (3% vs. 0%), but leukocyte counts and AST and CK concentrations were decreased immediately and 24 hours after surgery (all, p 1.7 and p