Undernutrition and Postnatal Development of Brain Oxidative Metabolism in Limbic Structures: A Quantitative Study.

The effects of food restriction during gestation, lactation and post-weaning were studied in rat brain structures (14,21 and 30 days). Oxidative metabolism was quantified in neurons from the anterior thalamus and mammillary bodies using a quantitative histochemical method for cytochrome c oxidase (CO). In all the rat brains studied, a significant increase in activity occurred in the control group from 14 to 21 days after birth which then remained constant up to 30 days. A similar pattern was observed in the undernourished group, although in the anterodorsal and anteromedial thalamic nuclei the rise in CO only occurred between day 14 and 30 and there were no significant age-related changes in the lateral mammillary nucleus. Undernutrition produced a significant drop in CO activity after 21 days in all the nuclei except the lateral mammillary nucleus. In the latter nucleus and also in the pars medialis of the medial mammillary nucleus this parameter decreased at 30 days. Our results suggest that undernutrit...