EFFECT OF THE LEU-ENKEPHALIN ANALOG DALARGIN ON DNA SYNTHESIS IN THE MYOCARDIUM AND LINGUAL EPITHELIUM OF RATS IN EARLY POSTNATAL ONTOGENY

The DNA synthesis is studied in the myocardium and lingual epithelium of 4–5-day-old rats 24 h after a single administration of the leu-enkephalin analog dalargin in a dose of 10 or 100 µg/kg. At 10 µg/kg, dalargin significantly decreases the number of DNA-synthesizing nuclei in the left atrium, while at 100 µg/kg it significantly decreases the number of DNA-synthesizing nuclei in the left atrium and both ventricles. Dalargin does not change the DNA synthesis in the lingual epithelial cells.