Does Apolipoprotein ɛ4 interact with age or sex in cognitive function after traumatic brain injury
2016
Objective: The APOE ɛ4 allele has been associated poorer cognitive
function following traumatic brain injury, however evidence to date
has proven equivocal. The aim of this study was to investigate the
impact of APOE ɛ4 on cognitive function following traumatic brain
injury, and to explore the influence of age and sex on the impact of
APOE ɛ4 versus the most common APOE allele; ɛ3. Participants and Methods: Participants with traumatic brain injury
were genotyped to determine APOE status and APOE ɛ4 and APOE
ɛ3 carriers were assessed using a battery of cognitive tasks
measuring executive function, working memory, and processing
speed at 3, 6 and 12 months post-injury. Results: Mixed modelling revealed that APOE ɛ4 carriers performed
worse than the APOE ɛ3 group on only two of seven tasks (Trail
Making Task B at 6 months, and the Controlled Oral Word
Association Task), and therefore possession of APOE ɛ4 did not
appear to systematically impair cognitive function. There was no
evidence of interactions between age and APOE ɛ4, or sex and
APOE ɛ4. Conclusions: Our findings indicate that the APOE gene is unlikely to
significantly impact on cognitive function following traumatic brain
injury, and that neither age nor sex interact with APOE ɛ4 in this
population. While the injury and demographic characteristics of our
sample were reflective of the broader TBI population, further
examination of these relationships in moderate to severe samples
may be warranted.
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