ОБГРУНТУВАННЯ ДОЦІЛЬНОСТІ ЗАСТОСУВАННЯ ДЕКАМЕТОКСИНУ ПРИ АНТИБІОТИКО– ТА ФАГОРЕЗИСТЕНТНОСТІ ПСЕВДОМОНАДНОЇ ХІРУРГІЧНОЇ ІНФЕКЦІЇ

Introduction. Pseudomonas aeruginosa (P. aeruginosa) constitutes a leading causative agent of infective complications in patients of combustiological departments. Objective. To substantiate expediency of decametoxinum application in P. aeruginosa resistance towards cephalosporines. Маterials and methods. Efficacy of decametoxinum application in overcoming of P. aeruginosa resistance towards cephalosporines, pseudomonadal bacteriophage on 50 clinical strains, taken in the injured persons, suffering burns, was studied. Results. There was established, that P. aeruginosa strains, which caused infection complications in injured persons with burns, have had pronounced resistance towards ceftazidim (in 80% of observations), cefepim (in 80%), cefoperazon/sulbactam (in 68%). Effective bactericidal action of decametoxinum towards 66% strains of P. aeruginosa was studied, minimal bactericidal concentration had constituted (106.1 ± 5.6) mcg/ml at average. Discussion. Sensitivity of P. aeruginosa towards bacteriophage and cephalosporines has been enhanced in presence of decametoxinum in subbacteriostatic concentration. Conclusion. Resistance towards cephalosporins strains of P. aeruginosa did not have cross sustainability towards decamethoxine, bacterіophage. Application of antiseptic decametoxinum in subbacteriostatic concentration have raised sensitivity of P. aeruginosa towards cephalosporines in 7 – 8.5 times; improved sensitivity of moderately stable phagoleasable cultures of P. aeruginosa towards bacteriophage.