p-Menthene-type Monoterpene Peroxy Dimers from Pilea aquarum subsp. brevicornuta

Abstract Chemical investigation on Pilea aquarum subsp. brevicornuta led to the identification of three previously unknown dimeric p-menthene-type monoterpene peroxides, pileadimenthenols A-C (1-3). Their chemical structures and absolute configurations were determined by extensive spectroscopic analyses, X-ray crystal diffraction and ECD calculations. Plausible biogenesis of 1-3 was also proposed. Among the isolates, 2 showed weak cytotoxic activity against HCT-116.