AmiodaroneAssociated Pulmonary Fibrosis

We studied the postmortem tissue specimens from a patient who had received amiodarone. The lung tissue displayed severe, diffuse interstitial fibrosis without the development of a significant inflammatory reaction. The case was studied morphologically, immunologically, and biochemically. The patient’s serum was found to be capable of reacting with his own lung tissue. The reaction was detected by immunofluorescence, and the serum component was identified as an IgG class antibody. The antibody could be absorbed by � ‘-. :, �: /.