Asymmetric synthesis of common aza-tricyclic core of various alkaloids

The asymmetric synthesis of common aza-tricyclic core of different types of natural alkaloids had been accomplished from commercially available L-Cbz-tyrosine. This practical approach was capable of generating scale-up aza-tricyclic skeleton. Meanwhile, it will facilitate the manipulating functionalities on the aza-tricyclic framework further, for the purpose of target-oriented synthesis of a large number of different natural alkaloids containing this versatile aza-tricyclic structure. (C) 2015 Elsevier Ltd. All rights reserved.