Effect of Fuzheng Peiben therapy on dendritic cell in patients with breast cancer

Objective: To investigate the repairing mechanism of Fuzheng Peiben Therapy on cellular immunofunction in patients with breast cancer on cellar and molecular level.Methods: The tumor tissue and axillary lymph node samples were evaluated with the flow cytometry for CD83,CD80,CD86 before and after neoadujvant therapy.Results: The levels of CD83,CD80,CD86 were singificantly decreased in group A(treated with surgery only),B(treated with neoadujvant chemotherapy plus surgery) and C(treated with neoadujvant chemotherapy plus surgery with shenqi Fuzheng Injection) compared with that in normal team(P0.05 or 0.01);The levels of CD83,CD80,CD86 were significantly decreased in group A,B and C compared between before and after neoadujvant chemotherapy(P0.05 or 0.01);They were not significantly decreased between group A and group C(P0.05).Conclusion: The cellular immunity was inpaired considerably by neoadujvant chemotherapy.Neoadjuvant chemotherapy combined with Shenqi Fuzheng Injection can enhance the cellular immunity considerably.