Ocular, Cutaneous, Respiratory, and Intratracheal Toxicity of Solutions of CS and EA 3547 in Glycol and Glycol Ether in Animals

Abstract : The studies described in this report were performed to assess the toxicities of o-chlorobenzylidene malononitrile (CS) and dibenz(b, f)-1, 4- oxazepine (EA 3547) in glycol ether solutions when administered to animals as follows: single and repeated doses in the eye, single and repeated doses on the skin, single and repeated doses applied to cloth on skin, single doses administered into the trachea, sprays of the solutions disseminated from the XM30, onto the eyes and skin, and inhalation of aerosols. The only residual damage seen when 1% CS in dipropylene glycol was applied to the skin and eyes of rabbits and monkeys occurred in the corneas of the rabbits that received the repeated doses. No residual damage was seen when 1% EA 3547 in dipropylene glycol and in propylene glycol was applied to the skin and eyes of rabbits and monkeys once or for five consecutive days. The same was true of 1% EA 3547 in diethylene glycol monomethyl ether in rabbits. When solutions of 1% CS in dipropylene glycol and 1% EA in dipropylene glycol, propylene glycol, or diethylene glycol monoethyl ether were administered intratracheally to dogs, no residual damage occurred. Rats and guinea pigs exposed to aerosols of 1% CS in dipropylene glycol, 1% EA 3547 in propylene glycol, and 1% EA 3547 in dipropylene glycol showed no residual pathological effects.