1850 CORRELATION OF URINARY OXIDANT STRESS MARKER LEVEL WITH THE RESPONSE OF ANTIMUSCARINIC THERAPY IN PATIENTS WITH FEMALE OVERACTIVE BLADDER

INTRODUCTION AND OBJECTIVES: Urinary retention is a well-documented complication of stress urinary incontinence (SUI) surgery. A common treatment for postoperative urinary retention and bothersome obstructive voiding symptoms following anti-incontinence surgery is urethrolysis. While previous studies have indicated a risk of recurrent SUI after urethrolysis, there is a paucity of data regarding patients requiring repeat anti-incontinence procedures. Thus, we sought to evaluate the incidence of repeat surgery for recurrent SUI after urethrolysis. METHODS: We performed a retrospective review of 100 consecutive female urethrolysis procedures at Mayo Clinic from January 2000 to September 2006 by two subspecialized urologists. Characteristics of this patient population were identified, specifically the incidence of subsequent anti-incontinence procedures. RESULTS: The mean patient age was 58 years (range 27-81), with a mean follow-up of 15 months. Patients required urethrolysis secondary to pubovaginal sling placement (50), Marshall-MarchettiKrantz procedure (12), transvaginal/suprapubic synthetic slings (23), Burch repair (5), transobturator sling (1), or other repair (9). Ultimately, 7/100 patients (7%) required repeat surgical intervention for recurrent SUI following initial urethrolysis (2 patients underwent bladder neck collagen injections, 4 women had placement of a pubovaginal sling and one patient had a suprapubic synthetic sling placed). CONCLUSIONS: Urethrolysis remains an important treatment option for patients with obstruction following surgery for SUI. Patients should be counseled that SUI may recur after urethrolysis, however, only a small percentage of patients require repeat surgical intervention for recurrent SUI.