Discovery of a new binding mode for a series of liver X receptor agonists.
2012
Abstract Structural modification of a series of dual LXRα/β agonists led to the identification of a new class of LXRβ partial agonists. An X-ray co-crystal structure shows that a representative member of this series, pyrrole 5 , binds to LXRβ with a reversed orientation compared to 1 .
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